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Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is an innovation-driven pharmaceutical company dedicated to the discovery, development, and commercialization of novel first-in-class drugs directed against nuclear export and related targets for the treatment of cancer and other major diseases. Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharm’s lead compound, XPOVIO® (selinexor), received accelerated approval from the U.S. Food and Drug Administration (FDA) in July 2019 in combination with dexamethasone as a treatment for patients with heavily pretreated multiple myeloma. In June 2020, XPOVIO was approved by the FDA as a treatment for patients with relapsed or refractory diffuse large B-cell lymphoma. A Marketing Authorization Application for selinexor for patients with heavily pretreated multiple myeloma is also currently under review by the European Medicines Agency. In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. 

Manufacturing & Electronics

Karyopharm Therapeutics Inc.

Manufacturing

Science & Healthcare

You need a B.A. or B.S., 2-3 years in contracts administration, eTMF experience, strong project management skills, and proficiency in MS Office and Adobe Acrobat.

You will draft and negotiate CDAs, manage clinical contracts, ensure compliance in contract systems, track expiration dates, support internal teams, and maintain eTMF documents.

Legal

Newton

<div>
 Role Overview &amp; Key Functions:: 
 <ul>
  <li>Responsible for drafting, reviewing and negotiating Confidential Disclosure Agreements (CDAs) with US and ex-US healthcare institutions.</li>
  <li>Support legal team with preparation, management and negotiation of routine U.S. and ex-U.S. clinical contract templates (e.g., drafting amendments, extensions and terminations, interpreting contractual language in response to issues or questions that arise)</li>
  <li>Serve in an administrative capacity for all clinical contract matters within the legal department (responsible for QC final drafts, execution process, distributing fully executed contracts, monitoring expiration dates of contracts, and contracts filing in accordance with appropriate records retention procedures)</li>
  <li>Timely tracking, maintenance and updating of company contract management systems to ensure accuracy and compliance with internal procedures and guidelines.</li>
  <li>Responsible for submitting and maintaining all clinical contract related agreements into eTMF systems. Manage the process for uploading, tracking, and managing department documents in eTMF</li>
  <li>Work closely with members of the Clinical Operations, Medical, Finance, Compliance and Site Payment teams and other internal clients, as well as external vendors with respect to specific contract request inquiries</li>
  <li>Ability to follow internal company processes with specific to contracting process guidelines related to contract management systems and department processes; offer and contribute to existing or new department process guidelines to ensure consistencies and improvements</li>
  <li>Other tasks that may be assigned from time to time to support overall function of legal team</li>
 </ul>
 <ul>
  <li><i>this position will be based in our Newton, MA office and is available for a hybrid work arrangement</i></li>
 </ul> Candidate Profile &amp; Requirements::<br>
 <p></p>
 <ul>
  <li>A. or B.S. degree required</li>
  <li>This role requires a minimum of 2-3 years strong administrative and project management skills as well as the ability to interact with a variety of stakeholders.</li>
  <li>Solid background as a contracts administrator, ideally in a pharmaceutical and/or biotech industry, with experience working cross functionally with business clients.</li>
  <li>Experience working with electronic Trial Master File (eTMF) systems for managing clinical trial documents.</li>
  <li>Ability to prioritize in a fast paced environment on multiple projects with changing priorities.</li>
  <li>Possess an understanding of global clinical development process and clinical operations – an advantage</li>
  <li>Ability to work independently with minimal supervision in a team-oriented environment</li>
  <li>Highly proficient with MS Word, Excel, and Adobe Acrobat. Grant Plan software – preferred</li>
 </ul><br>
 <div></div> Our Value Proposition:: 
 <p>At Karyopharm, we live and demonstrate our ICARE values every day!</p>
 <div></div>
 <div>
  <br> If you want to do something that matters, this work matters. Patients drive our passion to pioneer novel cancer therapies. That’s why we’ve built an environment centered around support, flexibility, and a shared mission.
 </div>
 <div>
  Creating and delivering medicine for cancer can only be done through focus, dedication, and heart. We hire exceptional people and trust each other to work in whatever way lets us, be us – whether that’s onsite, from home, or anywhere in between.
 </div>
 <div>
  What do you get when you pair an extraordinary mission with a culture of flexibility and empowerment? We invite you to find out and join us on this incredible mission.
 </div>
 <p></p>
 <p><br> Check out our Culture Video!</p>
 <div></div>
 <div>
  <br> What We Offer:
 </div>
 <div></div>
 <div>
  <br> In addition to our exciting, supportive, and intellectually challenging global workspaces(s), teamembers enjoy a comprehensive and generous benefits package (active on day one) that makes them more productive and contributes directly to the development of their professional skills.
 </div>
 <ul>
  <li>A culture of employee engagement, diversity, and inclusion</li>
  <li>Competitive salary, bonus, and generous equity offerings (RSU’s at time of offer and annual awards) – we are partners in prosperity!</li>
  <li>Peace of mind through best in class medical (deducible paid by KPTI), dental, vision, disability, and life insurance, parental leave, a matching 401k program (immediate vesting), ESPP and tuition reimbursement.</li>
  <li>Wellness Program with a monthly stipend.</li>
  <li>Generous PTO and Holidays – we encourage you to recharge and spend time with family and friends.</li>
  <li>Ample opportunities to learn and take on new responsibilities in a fast-paced, and patient focused company. (tuition reimbursement, management development &amp; mentoring programs, and a variety of reward and recognition programs)</li>
  <li>Cell phone allowance</li>
 </ul>
</div>


 Role Overview & Key Functions:: 
 
  Responsible for drafting, reviewing and negotiating Confidential Disclosure Agreements (CDAs) with US and ex-US healthcare institutions.
  Support legal team with preparation, management and negotiation of routine U.S. and ex-U.S. clinical contract templates (e.g., drafting amendments, extensions and terminations, interpreting contractual language in response to issues or questions that arise)
  Serve in an administrative capacity for all clinical contract matters within the legal department (responsible for QC final drafts, execution process, distributing fully executed contracts, monitoring expiration dates of contracts, and contracts filing in accordance with appropriate records retention procedures)
  Timely tracking, maintenance and updating of company contract management systems to ensure accuracy and compliance with internal procedures and guidelines.
  Responsible for submitting and maintaining all clinical contract related agreements into eTMF systems. Manage the process for uploading, tracking, and managing department documents in eTMF
  Work closely with members of the Clinical Operations, Medical, Finance, Compliance and Site Payment teams and other internal clients, as well as external vendors with respect to specific contract request inquiries
  Ability to follow internal company processes with specific to contracting process guidelines related to contract management systems and department processes; offer and contribute to existing or new department process guidelines to ensure consistencies and improvements
  Other tasks that may be assigned from time to time to support overall function of legal team
 
 
  this position will be based in our Newton, MA office and is available for a hybrid work arrangement
  Candidate Profile & Requirements::
 
 
  A. or B.S. degree required
  This role requires a minimum of 2-3 years strong administrative and project management skills as well as the ability to interact with a variety of stakeholders.
  Solid background as a contracts administrator, ideally in a pharmaceutical and/or biotech industry, with experience working cross functionally with business clients.
  Experience working with electronic Trial Master File (eTMF) systems for managing clinical trial documents.
  Ability to prioritize in a fast paced environment on multiple projects with changing priorities.
  Possess an understanding of global clinical development process and clinical operations – an advantage
  Ability to work independently with minimal supervision in a team-oriented environment
  Highly proficient with MS Word, Excel, and Adobe Acrobat. Grant Plan software – preferred
 
  Our Value Proposition:: 
 At Karyopharm, we live and demonstrate our ICARE values every day!
 
 
   If you want to do something that matters, this work matters. Patients drive our passion to pioneer novel cancer therapies. That’s why we’ve built an environment centered around support, flexibility, and a shared mission.
 
 
  Creating and delivering medicine for cancer can only be done through focus, dedication, and heart. We hire exceptional people and trust each other to work in whatever way lets us, be us – whether that’s onsite, from home, or anywhere in between.
 
 
  What do you get when you pair an extraordinary mission with a culture of flexibility and empowerment? We invite you to find out and join us on this incredible mission.
 
 
  Check out our Culture Video!
 
 
   What We Offer:
 
 
 
   In addition to our exciting, supportive, and intellectually challenging global workspaces(s), teamembers enjoy a comprehensive and generous benefits package (active on day one) that makes them more productive and contributes directly to the development of their professional skills.
 
 
  A culture of employee engagement, diversity, and inclusion
  Competitive salary, bonus, and generous equity offerings (RSU’s at time of offer and annual awards) – we are partners in prosperity!
  Peace of mind through best in class medical (deducible paid by KPTI), dental, vision, disability, and life insurance, parental leave, a matching 401k program (immediate vesting), ESPP and tuition reimbursement.
  Wellness Program with a monthly stipend.
  Generous PTO and Holidays – we encourage you to recharge and spend time with family and friends.
  Ample opportunities to learn and take on new responsibilities in a fast-paced, and patient focused company. (tuition reimbursement, management development & mentoring programs, and a variety of reward and recognition programs)
  Cell phone allowance
 


Karyopharm Therapeutics Inc.

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