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Principal Pharmacometrician

  • Job
    Full-time
    Senior Level
  • Research & Development
    Healthcare
  • Milan

AI generated summary

  • You must have a Ph.D. or PharmD, 5+ years in Pharma/CRO, PK analysis experience, proficiency in R and NONMEM, strong quantitative skills, excellent communication, and mentoring abilities.
  • You will design, analyze, interpret, and implement modeling and simulation for the clinical pharmacology team, ensuring effective outcomes in drug development.

Requirements

  • Ph.D. or PharmD. in relevant discipline (mathematics, statistics, pharmacokinetics, pharmaceutical sciences, bioengineering, etc), with an emphasis on clinical pharmacokinetics
  • 5+ years in the Pharmaceutical or CRO Industry
  • Must have experience with pharmacokinetic, medical, pharmaceutical and research concepts
  • Experience required in pharmacokinetic analysis and modeling with strong theoretical background; should have a proven record of accomplishments and publications
  • Must have experience and be proficient as a pharmacokinetic modeler using R and NONMEM software (familiarity with other modelling packages would be advantageous: Phoenix NLME, Simcyp, Gastroplus, Monolix, etc)
  • Strong quantitative skills to develop models with nonlinear behavior, mechanistic or semi-mechanistic components, including must have dose-response modeling experience, QTc analysis, CAR-T analysis, etc.
  • Competent in pharmacokinetic/pharmacodynamic theory
  • Excellent communication skills, both written and oral
  • Ability to guide and manage multiple projects, delivering within required timelines.
  • Self-starter, able to initiate work and motivate others
  • Ability to keep others informed of progress
  • Excellent problem solving capabilities and organizational skills
  • Ability and desire to support, mentor and train others within the team
  • Must have experience creating NONMEM dataset specifications using SDTM and ADaM datasets
  • Strong quantitative skills to develop models with nonlinear behavior, mechanistic or semi-mechanistic components, including must have dose-response modeling experience

Responsibilities

  • The Principal Pharmacometrician role is responsible for overseeing the design, analysis, interpretation and implementation of modelling and simulation within the clinical pharmacology team.

FAQs

What are the work hours for the Principal Pharmacometrician position?

The work hours are standard office hours, which is 40 hours per week.

What kind of environment will I be working in?

You will be working in an office environment.

What qualifications are required for the Principal Pharmacometrician role?

A Ph.D. or PharmD. in a relevant discipline (such as mathematics, statistics, pharmacokinetics, pharmaceutical sciences, or bioengineering) with an emphasis on clinical pharmacokinetics is required.

How much experience is needed for this position?

Candidates should have 5+ years of experience in the Pharmaceutical or CRO Industry.

What specific skills are necessary for this role?

Proficiency as a pharmacokinetic modeler using R and NONMEM software, experience in dose-response modeling, QTc analysis, and CAR-T analysis, as well as strong quantitative skills are necessary.

Will I need to manage projects as a Principal Pharmacometrician?

Yes, the role requires the ability to guide and manage multiple projects while delivering within required timelines.

Is experience in creating NONMEM dataset specifications required?

Yes, candidates must have experience creating NONMEM dataset specifications using SDTM and ADaM datasets.

What types of benefits does Thermo Fisher Scientific offer?

The company offers competitive remuneration, an annual incentive plan bonus, healthcare, and a range of employee benefits.

Is there an opportunity for professional development in this role?

Yes, Thermo Fisher Scientific provides outstanding career and development prospects and fosters a supportive culture for mentorship and training.

Are there publication requirements for this position?

Yes, candidates should have a proven record of accomplishments and publications in the relevant field.

The World Leader In Serving Science

Science & Healthcare
Industry
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Employees

Mission & Purpose

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.