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Denali Therapeutics is dedicated to defeating neurodegenerative diseases by breaking through historical barriers in scientific research and clinical development in order to deliver safe and effective medicines to patients and families.  Our scientific approach is based on three core principles: rigorous assessment of genetic targets, engineering brain delivery, and using biomarkers to guide development.

Our team thrives in a work environment that is scientifically driven, impact-focused, supportive, and collaborative. Our ability to have a positive impact on people’s lives is directly related to the trust we have in each other and our ability to unify our diverse backgrounds and experience behind our purpose to defeat degeneration.

Science & Healthcare

Denali Therapeutics

You must be a rising junior or above in science/engineering, have strong communication skills, be collaborative, energetic, and ideally have lab or manufacturing experience.

You will research and assess vendors for consumables, analyze product offerings, evaluate production impacts, and prepare detailed proposals for alternative suppliers.

Research & Development

Engineering

Salt Lake City

<div>Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
The Opportunity
We are seeking a motivated intern for the summer of 2025 to identify and propose ways to optimize the single-use consumable materials Denali uses within the manufacturing process. The project will include both improvements to selection and design of consumable materials from the OEM, as well as an evaluation of alternative suppliers for consumables that are interchangeable. This project aims to optimize and diversify our supply chain for critical components such as media/buffer bags, sampling assemblies, and tubing connectors and manifolds. The intern will work alongside a team with extensive experience to support the Denali site that is part of the SLC biotech community. The ideal candidate will be a highly motivated student who has a strong scientific and/or engineering background (e.g. biology, engineering), is intellectually curious, flexible, and enjoys working within a collaborative team setting.
Responsibilities<ul><li>
Identify commonly used consumables that contain typically unused and/or expensive components and propose alternative solutions.</li><li>
Research and identify potential alternative vendors for specified single-use consumables.</li><li>
Interact with existing and prospective vendors to gather information on their products, capabilities, and supply chain processes.</li><li>
Conduct comparative analyses of vendor offerings, considering factors such as:<ul><li>
Product quality and compatibility with Cytiva flex factory designs</li><li>
Production capacity and scalability</li><li>
Supply chain reliability and risk factors</li><li>
Pricing and potential cost savings</li></ul></li><li>
Potential improvements to reduce the number and/or complexity of current assemblies</li><li>
Evaluate the potential impact of alternative vendors on our production processes and final product quality.</li><li>
Regulatory compliance and quality assurance measures</li><li>
Accurate and timely recording of work time by clocking in and out using designated timekeeping systems. Adherence to company timekeeping policies, including rules regarding overtime, meal breaks, and reporting procedures for any discrepancies.</li><li>
Prepare a comprehensive proposal for consideration of future alternative vendors, including:<ul><li>
Detailed vendor profiles and assessments</li><li>
Cost-benefit analysis of switching to alternative suppliers</li><li>
Risk assessment and mitigation strategies</li><li>
Recommendations for next steps and potential pilot program</li></ul></li><li>
Accurate and timely recording of work time by clocking in and out using designated timekeeping systems. Adherence to company timekeeping policies, including rules regarding overtime, meal breaks, and reporting procedures for any discrepancies.</li></ul>
Position requirements:<ul><li>
Rising junior or above pursuing a BS or MS (science/engineering) with significant interest in biotech/pharma operations and manufacturing</li><li>
Excellent oral and written communication skills</li><li>
Energetic, and self-motivated with ability to work in a highly collaborative environment</li><li>
Experience working in a lab or manufacturing setting is highly desirable.</li></ul>
The expected wage for this position based on the Salt Lake City, Utah office location for BA/BS is $22.11 per hour and for MS $27.40 per hour. Paid holiday time off is based on Denali's designated holidays. Interns who live more than 50 miles away from the office are eligible for an additional housing stipend.
Job Facts
<div><ul><li>Start Date: Summer 2025</li><li>
Length of Assignment: 10 - 12 weeks</li><li>
Location: Salt Lake City, UT</li><li>
Job Type: Paid Internship</li></ul></div>
This compensation and benefits information is based on Denali&rsquo;s good faith estimate as of the date of publication and may be modified in the future. 
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.</div>

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
The Opportunity
We are seeking a motivated intern for the summer of 2025 to identify and propose ways to optimize the single-use consumable materials Denali uses within the manufacturing process. The project will include both improvements to selection and design of consumable materials from the OEM, as well as an evaluation of alternative suppliers for consumables that are interchangeable. This project aims to optimize and diversify our supply chain for critical components such as media/buffer bags, sampling assemblies, and tubing connectors and manifolds. The intern will work alongside a team with extensive experience to support the Denali site that is part of the SLC biotech community. The ideal candidate will be a highly motivated student who has a strong scientific and/or engineering background (e.g. biology, engineering), is intellectually curious, flexible, and enjoys working within a collaborative team setting.
Responsibilities
Identify commonly used consumables that contain typically unused and/or expensive components and propose alternative solutions.
Research and identify potential alternative vendors for specified single-use consumables.
Interact with existing and prospective vendors to gather information on their products, capabilities, and supply chain processes.
Conduct comparative analyses of vendor offerings, considering factors such as:
Product quality and compatibility with Cytiva flex factory designs
Production capacity and scalability
Supply chain reliability and risk factors
Pricing and potential cost savings
Potential improvements to reduce the number and/or complexity of current assemblies
Evaluate the potential impact of alternative vendors on our production processes and final product quality.
Regulatory compliance and quality assurance measures
Accurate and timely recording of work time by clocking in and out using designated timekeeping systems. Adherence to company timekeeping policies, including rules regarding overtime, meal breaks, and reporting procedures for any discrepancies.
Prepare a comprehensive proposal for consideration of future alternative vendors, including:
Detailed vendor profiles and assessments
Cost-benefit analysis of switching to alternative suppliers
Risk assessment and mitigation strategies
Recommendations for next steps and potential pilot program
Accurate and timely recording of work time by clocking in and out using designated timekeeping systems. Adherence to company timekeeping policies, including rules regarding overtime, meal breaks, and reporting procedures for any discrepancies.
Position requirements:
Rising junior or above pursuing a BS or MS (science/engineering) with significant interest in biotech/pharma operations and manufacturing
Excellent oral and written communication skills
Energetic, and self-motivated with ability to work in a highly collaborative environment
Experience working in a lab or manufacturing setting is highly desirable.
The expected wage for this position based on the Salt Lake City, Utah office location for BA/BS is $22.11 per hour and for MS $27.40 per hour. Paid holiday time off is based on Denali's designated holidays. Interns who live more than 50 miles away from the office are eligible for an additional housing stipend.
Job Facts
Start Date: Summer 2025
Length of Assignment: 10 - 12 weeks
Location: Salt Lake City, UT
Job Type: Paid Internship
This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Intern, Manufacturing Science & Technology (MSAT) - Denali Therapeutics

<div>
 Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
 
 We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
 
 The Opportunity
 
 We are seeking a motivated intern for the summer of 2025 to identify and propose ways to optimize the single-use consumable materials Denali uses within the manufacturing process. The project will include both improvements to selection and design of consumable materials from the OEM, as well as an evaluation of alternative suppliers for consumables that are interchangeable. This project aims to optimize and diversify our supply chain for critical components such as media/buffer bags, sampling assemblies, and tubing connectors and manifolds. The intern will work alongside a team with extensive experience to support the Denali site that is part of the SLC biotech community. The ideal candidate will be a highly motivated student who has a strong scientific and/or engineering background (e.g. biology, engineering), is intellectually curious, flexible, and enjoys working within a collaborative team setting.
 
 Responsibilities
 <ul>
 <li>Identify commonly used consumables that contain typically unused and/or expensive components and propose alternative solutions.</li>
 <li>Research and identify potential alternative vendors for specified single-use consumables.</li>
 <li>Interact with existing and prospective vendors to gather information on their products, capabilities, and supply chain processes.</li>
 <li>Conduct comparative analyses of vendor offerings, considering factors such as:
 <ul>
 <li>Product quality and compatibility with Cytiva flex factory designs</li>
 <li>Production capacity and scalability</li>
 <li>Supply chain reliability and risk factors</li>
 <li>Pricing and potential cost savings</li>
 </ul></li>
 <li>Potential improvements to reduce the number and/or complexity of current assemblies</li>
 <li>Evaluate the potential impact of alternative vendors on our production processes and final product quality.</li>
 <li>Regulatory compliance and quality assurance measures</li>
 <li>Accurate and timely recording of work time by clocking in and out using designated timekeeping systems. Adherence to company timekeeping policies, including rules regarding overtime, meal breaks, and reporting procedures for any discrepancies.</li>
 <li>Prepare a comprehensive proposal for consideration of future alternative vendors, including:
 <ul>
 <li>Detailed vendor profiles and assessments</li>
 <li>Cost-benefit analysis of switching to alternative suppliers</li>
 <li>Risk assessment and mitigation strategies</li>
 <li>Recommendations for next steps and potential pilot program</li>
 </ul></li>
 <li>Accurate and timely recording of work time by clocking in and out using designated timekeeping systems. Adherence to company timekeeping policies, including rules regarding overtime, meal breaks, and reporting procedures for any discrepancies.</li>
 </ul>
 
 Position requirements:
 <ul>
 <li>Rising junior or above pursuing a BS or MS (science/engineering) with significant interest in biotech/pharma operations and manufacturing</li>
 <li>Excellent oral and written communication skills</li>
 <li>Energetic, and self-motivated with ability to work in a highly collaborative environment</li>
 <li>Experience working in a lab or manufacturing setting is highly desirable.</li>
 </ul>
 
 The expected wage for this position based on the Salt Lake City, Utah office location for BA/BS is $22.11 per hour and for MS $27.40 per hour. Paid holiday time off is based on Denali's designated holidays. Interns who live more than 50 miles away from the office are eligible for an additional housing stipend.
 
 Job Facts 
 <div>
 <ul>
 <li>Start Date: Summer 2025</li>
 <li>Length of Assignment: 10 - 12 weeks</li>
 <li>Location: Salt Lake City, UT</li>
 <li>Job Type: Paid Internship</li>
 </ul>
 </div>
 
 This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
 Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
</div>

Intern, Manufacturing Science & Technology (MSAT)

You need a Bachelor's degree, 4+ years in pharma with 2+ years in trial management, strong organizational and communication skills, and the ability to manage priorities and solve problems.

You will manage study operations, ensure compliance with GCP/ICH, oversee vendors, conduct feasibility assessments, train staff, review budgets, and maintain study quality and documentation.

Healthcare

South San Francisco

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Key Accountabilities/Core Job Responsibilities * Lead/support: internal cross-functional study execution team for assigned stud(ies) and/or assigned stud(ies); preparation of vendor requirements and project scope and selection of study vendors. * Manage and lead the day-to-day operations of assigned studies to ensure completion per established project team goals and objectives in compliance with applicable GCP/ICH guidelines and other regulatory requirements. This includes managing clinical research organizations to ensure timely and quality deliverables. * Lead/support feasibility assessment and selection of countries and sites for study conduct, development of study plans, system set-up and UAT to ensure operational excellence of protocol, CRF, CSR and other key study deliverables. * Implement appropriate systems, standards and processes to ensure quality at the level of investigative sites, vendors and data; maintain clinical study files per ICH guidance. * Oversee the quality of the clinical trial master files as well as the clinical aspects of timely data cleaning, data analysis and the availability of top line results; participate in data reviews and review of statistical analysis plans. * Author, audit and/or edit written summaries of data reports, presentations, training material, and study documents (including pharmacy, laboratory, and operations manuals). * Ensure set-up and implementation of effective investigator and site monitor training, create and conduct study-specific training at investigator meetings. * Review study invoices and participate in accrual reviews to track the financial status of the study against budget. * Ensure that all work adheres to ICH Good Clinical Practice (GCP) guidelines and comply with company SOPs. Qualifications/Skills * Bachelor’s degree required. RN/PA with professional clinical experience, and/or Master’s degree or higher in health-related science or equivalent preferred. * 4+ years in a pharmaceutical setting (sponsor side experience a plus) with 2+ years of trial management experience required. * Excellent organizational skills and attention to detail. * Effective communication and interpersonal skills. * Ability to efficiently perform multiple tasks and manage changing priorities. * Ability to identify and solve logistical problems. * Ability to build strong relationships with co-workers of various backgrounds and expertise. * Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor. Salary Range: $136,000.00 to $157,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.Key Accountabilities/Core Job Responsibilities * Lead/support: internal cross-functional study execution team for assigned stud(ies) and/or assigned stud(ies); preparation of vendor requirements and project scope and selection of study vendors. * Manage and lead the day-to-day operations of assigned studies to ensure completion per established project team goals and objectives in compliance with applicable GCP/ICH guidelines and other regulatory requirements. This includes managing clinical research organizations to ensure timely and quality deliverables. * Lead/support feasibility assessment and selection of countries and sites for study conduct, development of study plans, system set-up and UAT to ensure operational excellence of protocol, CRF, CSR and other key study deliverables. * Implement appropriate systems, standards and processes to ensure quality at the level of investigative sites, vendors and data; maintain clinical study files per ICH guidance. * Oversee the quality of the clinical trial master files as well as the clinical aspects of timely data cleaning, data analysis and the availability of top line results; participate in data reviews and review of statistical analysis plans. * Author, audit and/or edit written summaries of data reports, presentations, training material, and study documents (including pharmacy, laboratory, and operations manuals). * Ensure set-up and implementation of effective investigator and site monitor training, create and conduct study-specific training at investigator meetings. * Review study invoices and participate in accrual reviews to track the financial status of the study against budget. * Ensure that all work adheres to ICH Good Clinical Practice (GCP) guidelines and comply with company SOPs.      Qualifications/Skills * Bachelor’s degree required. RN/PA with professional clinical experience, and/or Master’s degree or higher in health-related science or equivalent preferred. * 4+ years in a pharmaceutical setting (sponsor side experience a plus) with 2+ years of trial management experience required. * Excellent organizational skills and attention to detail. * Effective communication and interpersonal skills. * Ability to efficiently perform multiple tasks and manage changing priorities. * Ability to identify and solve logistical problems. * Ability to build strong relationships with co-workers of various backgrounds and expertise. * Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor.      Salary Range: $136,000.00 to $157,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careersThis compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Clinical Trial Manager - Denali Therapeutics

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;br&gt;&lt;br&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;br&gt;&lt;br&gt;&lt;strong&gt;Key Accountabilities/Core Job Responsibilities&lt;br&gt;&lt;br&gt;&lt;/strong&gt;&lt;ul&gt;&lt;li&gt;Lead/support: internal cross-functional study execution team for assigned stud(ies) and/or assigned stud(ies); preparation of vendor requirements and project scope and selection of study vendors.&lt;/li&gt;&lt;li&gt;Manage and lead the day-to-day operations of assigned studies to ensure completion per established project team goals and objectives in compliance with applicable GCP/ICH guidelines and other regulatory requirements. This includes managing clinical research organizations to ensure timely and quality deliverables.&lt;/li&gt;&lt;li&gt;Lead/support feasibility assessment and selection of countries and sites for study conduct, development of study plans, system set-up and UAT to ensure operational excellence of protocol, CRF, CSR and other key study deliverables.&lt;/li&gt;&lt;li&gt;Implement appropriate systems, standards and processes to ensure quality at the level of investigative sites, vendors and data; maintain clinical study files per ICH guidance.&lt;/li&gt;&lt;li&gt;Oversee the quality of the clinical trial master files as well as the clinical aspects of timely data cleaning, data analysis and the availability of top line results; participate in data reviews and review of statistical analysis plans.&lt;/li&gt;&lt;li&gt;Author, audit and/or edit written summaries of data reports, presentations, training material, and study documents (including pharmacy, laboratory, and operations manuals).&lt;/li&gt;&lt;li&gt;Ensure set-up and implementation of effective investigator and site monitor training, create and conduct study-specific training at investigator meetings.&lt;/li&gt;&lt;li&gt;Review study invoices and participate in accrual reviews to track the financial status of the study against budget.&lt;/li&gt;&lt;li&gt;Ensure that all work adheres to ICH Good Clinical Practice (GCP) guidelines and comply with company SOPs.&lt;br&gt;&lt;br&gt;&lt;/li&gt;&lt;/ul&gt;&lt;strong&gt;Qualifications/Skills&lt;br&gt;&lt;br&gt;&lt;/strong&gt;&lt;ul&gt;&lt;li&gt;Bachelor’s degree required. RN/PA with professional clinical experience, and/or Master’s degree or higher in health-related science or equivalent preferred.&lt;/li&gt;&lt;li&gt;4+ years in a pharmaceutical setting (sponsor side experience a plus) with 2+ years of trial management experience required.&lt;/li&gt;&lt;li&gt;Excellent organizational skills and attention to detail.&lt;/li&gt;&lt;li&gt;Effective communication and interpersonal skills.&lt;/li&gt;&lt;li&gt;Ability to efficiently perform multiple tasks and manage changing priorities.&lt;/li&gt;&lt;li&gt;Ability to identify and solve logistical problems.&lt;/li&gt;&lt;li&gt;Ability to build strong relationships with co-workers of various backgrounds and expertise.&lt;/li&gt;&lt;li&gt;Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor.&lt;br&gt;&lt;br&gt;&lt;/li&gt;&lt;/ul&gt;Salary Range: $136,000.00 to $157,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers&lt;br&gt;&lt;br&gt;This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.&lt;br&gt;&lt;br&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Denali Therapeutics

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