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Postdoctoral Fellow – Design of Pro-Groups for Covalent Modalities

  • Job
    Full-time
    Entry, Junior, Mid & Senior Level
  • Science
    Research & Development
  • London
  • Quick Apply

AI generated summary

  • You need a PhD in synthetic organic/medicinal chemistry, curiosity about new modalities, collaboration skills, strong publications, and knowledge in chemical biology and physical organic chemistry.
  • You will design and synthesize pro-groups, conduct validation studies, develop payloads for drug conjugates, and publish research while collaborating with a cross-functional team and an academic mentor.

Requirements

  • PhD degree in synthetic organic or medicinal chemistry
  • Curiosity about working with new modalities; such as PROTACs, peptide and/or antibody drug conjugates
  • Ability to collaborate and work optimally in a multi-disciplinary research environment
  • Excellent written and oral communication skills
  • Our Postdoc programme is aimed at individuals with a strong publication record who are either:
  • Within 5-years of acquiring their doctoral degree (PhD, DVM, or MD) - PhD already awarded, or
  • Students, soon to acquire doctoral degrees (the PhD must be awarded within 6 months of joining AstraZeneca).
  • Experience of, or a keen interest in: chemical biology, biochemical assays/protein labelling and computational modelling techniques
  • Knowledge of current principles and concepts in physical organic chemistry

Responsibilities

  • Develop novel chemistries, rationally designing and synthesising pro-groups for the masking of covalent motifs
  • Carry out validation studies through biochemical and in vitro assays and protein labelling experiments
  • Synthesis of novel payloads and linker-payloads for application as antibody drug conjugates
  • Build independent scientific leadership and research skills, drive the project forward under the supervision of a cross-functional AstraZeneca team and in collaboration with the academic mentor
  • Plan, write and publish high-quality scientific manuscripts and present work at external and internal meetings, conferences and seminars

FAQs

What is the location of the Postdoctoral Fellow position?

The position is located in Whitechapel, London.

What is the duration of the Postdoctoral Fellowship program?

The program is a 3-year fellowship.

What kind of support will the Postdoctoral Fellow receive?

The Fellow will receive mentorship from Ben Graham, Senior Scientist at AstraZeneca, as well as academic guidance from Prof. Gonçalo Bernardes, Professor of Chemical Biology at the University of Cambridge.

What are the key responsibilities of the Postdoctoral Fellow?

Key responsibilities include developing novel chemistries, conducting validation studies, synthesizing novel payloads, building scientific leadership, and publishing research findings.

What educational qualifications are required for this position?

A PhD degree in synthetic organic or medicinal chemistry is required.

What types of research modalities will the Postdoctoral Fellow work with?

The Fellow will work with new modalities such as PROTACs, peptide, and antibody drug conjugates.

Is collaboration with other scientists encouraged in this role?

Yes, the role requires collaboration and optimal functioning within a multi-disciplinary research environment.

What experience or skills are considered desirable for candidates?

Desirable skills include experience in chemical biology, biochemical assays, protein labeling, and knowledge of physical organic chemistry principles.

Does AstraZeneca have flexibility in working arrangements?

Yes, AstraZeneca balances the expectation of in-office work with respect for individual flexibility, requiring a minimum of three days per week in the office.

How can candidates apply for this Postdoctoral position?

Candidates can apply through the AstraZeneca careers website or the provided links.

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Mission & Purpose

We're transforming the future of healthcare by unlocking the power of what science can do for people, society and the planet. AstraZeneca is a global pharmaceutical company dedicated to improving the health and well-being of people worldwide. With a focus on innovative research and development, AstraZeneca develops and manufactures a wide range of prescription medicines, including treatments for cardiovascular, respiratory, oncology, and other therapeutic areas. Their aim is to transform the lives of patients by discovering, developing, and delivering innovative medicines that address unmet medical needs. AstraZeneca's purpose is to push the boundaries of science and collaborate with healthcare professionals, organisations, and communities to improve patient outcomes and contribute to the advancement of healthcare globally.