You must have experience in producing recombinant multi-protein assemblies in insect or mammalian cells, plus knowledge of quantitative biophysical techniques for macromolecular interaction characterization.

You will reconstitute and characterize protein complexes for DNA repair using biochemical methods, protein engineering, and advanced biophysical techniques.

Science

Research & Development

United Kingdom

Cambridge

Large

The University of Cambridge is one of the world's foremost research universities.

The University is made up of 31 Colleges and over 150 departments, faculties, schools and other institutions. Its mission is 'to contribute to society through the pursuit of education, learning, and research at the highest international levels of excellence'​.



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University of Cambridge

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Applications are invited for a Research Associate position in the laboratory of Professor Luca Pellegrini in the Department of Biochemistry, University of Cambridge, UK. The successful applicant will work on biochemical reconstitution and structural characterisation of protein complexes important for Homology-Directed DNA Repair and genomic stability, see for instance Appleby et al, Nat Comm, 2023 (doi: 10.1038/s41467-023-42830-1); Hanthui YW et al, Mol Cell, 2024 (doi: 10.1016/j.molcel.2024.07.004). To achieve this goal, the successful candidate will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and state-of-the-art biophysical and structural techniques. In-depth experience of production of recombinant multi-protein assemblies by expression in insect cells and/or mammalian cells is required. Knowledge of quantitiative biophysical techniques for characterisation of macromolecular interactions would be an important advantage. The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA) and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualised metrics in their applications. For more information: https://www.research-strategy.admin.cam.ac.uk/research-policy/DORA Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and contact information for at least two referees. The funding is available from 01 December 2024. Fixed-term: The funds for this post are available until 31 May 2026 in the first instance. Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online. Informal enquiries are welcomed and should be directed to Professor Luca Pellegrini: lp212@cam.ac.uk For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk. Please quote reference PH43820 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Further information * Further Particulars Apply online

Applications are invited for a Research Associate position in the laboratory of Professor Luca Pellegrini in the Department of Biochemistry, University of Cambridge, UK.The successful applicant will work on biochemical reconstitution and structural characterisation of protein complexes important for Homology-Directed DNA Repair and genomic stability, see for instance Appleby et al, Nat Comm, 2023 (doi: 10.1038/s41467-023-42830-1); Hanthui YW et al, Mol Cell, 2024 (doi: 10.1016/j.molcel.2024.07.004).To achieve this goal, the successful candidate will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and state-of-the-art biophysical and structural techniques. In-depth experience of production of recombinant multi-protein assemblies by expression in insect cells and/or mammalian cells is required. Knowledge of quantitiative biophysical techniques for characterisation of macromolecular interactions would be an important advantage.The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA) and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualised metrics in their applications. For more information: https://www.research-strategy.admin.cam.ac.uk/research-policy/DORAApplicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and contact information for at least two referees.The funding is available from 01 December 2024.Fixed-term: The funds for this post are available until 31 May 2026 in the first instance.Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.Informal enquiries are welcomed and should be directed to Professor Luca Pellegrini: lp212@cam.ac.ukFor any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk.Please quote reference PH43820 on your application and in any correspondence about this vacancy.The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.The University has a responsibility to ensure that all employees are eligible to live and work in the UK.Further information * Further Particulars      Apply online

Research Associate- Pellegrini Group (Fixed Term) - University of Cambridge

Applications are invited for a Research Associate position in the laboratory of Professor Luca Pellegrini in the Department of Biochemistry, University of Cambridge, UK.&lt;br&gt;&lt;br&gt;The successful applicant will work on biochemical reconstitution and structural characterisation of protein complexes important for Homology-Directed DNA Repair and genomic stability, see for instance Appleby et al, Nat Comm, 2023 (doi: 10.1038/s41467-023-42830-1); Hanthui YW et al, Mol Cell, 2024 (doi: 10.1016/j.molcel.2024.07.004).&lt;br&gt;&lt;br&gt;To achieve this goal, the successful candidate will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and state-of-the-art biophysical and structural techniques. In-depth experience of production of recombinant multi-protein assemblies by expression in insect cells and/or mammalian cells is required. Knowledge of quantitiative biophysical techniques for characterisation of macromolecular interactions would be an important advantage.&lt;br&gt;&lt;br&gt;The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA) and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualised metrics in their applications. For more information: https://www.research-strategy.admin.cam.ac.uk/research-policy/DORA&lt;br&gt;&lt;br&gt;Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and contact information for at least two referees.&lt;br&gt;&lt;br&gt;The funding is available from 01 December 2024.&lt;br&gt;&lt;br&gt;Fixed-term: The funds for this post are available until 31 May 2026 in the first instance.&lt;br&gt;&lt;br&gt;Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.&lt;br&gt;&lt;br&gt;Informal enquiries are welcomed and should be directed to Professor Luca Pellegrini: lp212@cam.ac.uk&lt;br&gt;&lt;br&gt;For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk.&lt;br&gt;&lt;br&gt;Please quote reference PH43820 on your application and in any correspondence about this vacancy.&lt;br&gt;&lt;br&gt;The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.&lt;br&gt;&lt;br&gt;The University has a responsibility to ensure that all employees are eligible to live and work in the UK.&lt;br&gt;&lt;br&gt;Further information&lt;br&gt;&lt;br&gt;&lt;ul&gt;&lt;li&gt;Further Particulars&lt;br&gt;&lt;br&gt;&lt;/li&gt;&lt;/ul&gt;Apply online

Research Associate- Pellegrini Group (Fixed Term)

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