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Research Associate - Protein Engineering in the Advanced Protein Therapeutics Facility

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University of Texas at Austin

Sep 19

  • Job
    Full-time
    Junior Level
  • Austin
  • Quick Apply

AI generated summary

  • You need a Ph.D. in a relevant field, lab research experience, strong problem-solving skills, and proficiency in specific software. Experience in cancer biology and protein engineering techniques is preferred.
  • You will conduct literature research, execute experiments (cloning, protein expression, assays), maintain records, mentor others, assist with manuscripts and grants, and support lab activities.

Requirements

  • A Ph.D. in a relevant science/engineering discipline (e.g., biotechnology, biology, biochemistry, microbiology, chemical engineering, biomedical engineering) and academic research experience in a relevant lab environment.
  • We seek an enthusiastic and creative scientist/engineer passionate about developing anti-cancer therapeutics.
  • The successful candidate will be able to devise strategies to engineer and evaluate antibodies and other protein therapies against a given target, present these strategies, incorporate feedback, and design experimental systems to carry out the agreed upon strategies.
  • Training in specific techniques will be provided as needed.
  • This individual will have excellent verbal and written communication skills, as well as time management, organization and record keeping practices.
  • They will also have the ability to work independently and creatively, with strong problem-solving skills that use quantitative strategies to plan experiments and analyze data.
  • They will also be highly communicative and take initiative in communicating with others.
  • Proficiency with the Microsoft Office suite of programs, PyMol or equivalent, Benchling or equivalent, GraphPad or equivalent are required.
  • The ability to work collaboratively in an interdisciplinary environment is also required.
  • A Ph.D. degree and research experience in cancer biology or virology with relevant experience in mammalian cell culture and assay development is preferred.
  • Other relevant experience includes cloning, protein production and characterization, and library design, construction, and screening.
  • Specific experience with FPLC purification, measurement of protein-protein binding kinetics (ELISA, biolayer interferometry, surface plasmon resonance), protein engineering platforms (phage, yeast and/or mammalian libraries), flow cytometry, high throughput sequencing preparation and post-sequencing analysis, confocal microscopy, cellular assays for immune functions using cell lines and PBMCs, and animal models of cancer are all highly relevant skills that will be taken into account during hiring.
  • We are seeking bright, engaged, and considerate researchers above all else, so please consider applying if you lack some specific experience but are otherwise qualified.

Responsibilities

  • Responsibilities
  • Literature research and development of experimental strategies to meet goals as set by APT leadership.
  • Execution of project-specific experiments including cloning, protein expression, RNA extraction, high-throughput sequencing, cell culture (bacterial, yeast, mammalian), protein library design, construction, & screening, protein characterization (thermal stability, ELISA, BLI, SPR, SDS-PAGE, Western Blot, etc), cellular assays, and syngeneic mouse models.
  • Maintain detailed records of work performed, organization of items generated and development of SOPs. Prepare manuscripts for publication and data reports for sharing with scientists and collaborators. Assist with grant writing to move projects to the next level as needed.
  • Provide support for general lab activities, including teaching and mentoring less experienced researchers, developing new assays, and maintaining equipment.
  • Other related duties as assigned.

FAQs

What is the required education for the Research Associate position?

A Ph.D. in a relevant science or engineering discipline (e.g., biotechnology, biology, biochemistry, microbiology, chemical engineering, biomedical engineering) is required for this position.

How many years of post-doctoral research experience is needed?

The position requires 2 or more years of post-doctoral research experience.

What are the primary responsibilities of the Research Associate?

Responsibilities include literature research, executing project-specific experiments, maintaining detailed records, preparing manuscripts, mentoring less experienced researchers, and supporting general lab activities.

Which specific experimental techniques are mentioned as part of the job responsibilities?

The responsibilities include cloning, protein expression, RNA extraction, cell culture, protein library design, characterization, and cellular assays, among others.

What software proficiency is required for the position?

Proficiency in Microsoft Office, PyMol or equivalent, Benchling or equivalent, and GraphPad or equivalent is required.

Is the position full-time?

Yes, the position is full-time with a weekly scheduled hours of 40.

What is the salary range for this position?

The salary range for the position starts at $70,000 and may increase depending on qualifications.

What kind of lab environment can be expected?

The lab may work around biosafety hazards and chemicals, and laboratory work will require manual dexterity and mobility.

What materials are required to apply for this position?

Applicants must submit a CV, two professional references, and a letter of interest to apply for this position.

How long is the expected duration of the position?

The position is expected to continue until November 30, 2027.

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University of Texas at Austin

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Mission & Purpose

The University of Texas at Austin is one of the largest public universities in the United States. Founded in 1883, the University has grown from a single building, eight teachers, two departments and 221 students to a 350-acre main campus with 21,000 faculty and staff, 16 colleges and schools and more than 50,000 students.